Groundwater in Phu My town is exploited essentially in Pleistocene aquifer and, used for many purposes like irrigation, domestic, production and animal husbandry. In this study, Groundwater Quality Index (EWQI) is calculated with Entropy weight method to determine the suitability of groundwater quality in study area. This method demonstrates the objectivity of each parameter calculated based on the degree of variability of each value and depends on the sample data source. The groundwater samples were collected from 17 wells in dry and wet seasons in 2017 with ten water quality parameters (pH, TDS, TH, Cl-, F-, NH4+-N, NO3--N, SO42-, Pb và Fe2+) were selected for analysising. The analysis results indicate groundwater quality is divided into 4 categories in this study area. In particular, over 70% of wells are "very good" water quality in both dry and wet seasons. Only 6% of wells are " water unsuitable for drinking purpose" of the total number of mornitoring wells in the study area.