Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Review criteriaWe searched PubMed for articles in all year ranges with multiple combinations of search terms including, "post-haemorrhagic hydrocephalus", "post-infectious hydrocephalus", "worldwide", "epidemiology", "ETV/CPC", "VP Shunt", "NKCC1", "SPAK", "Toll-like receptors" "inflammation", "obstruction", "impaired reabsorption", "CSF hypersecretion", "cerebrospinal fluid". There were no language exclusions and articles chosen were based on relevance to topics covered in this Review. Peer review information Nature Reviews Neurology thanks [Referee# 1 name], [Referee#2 name] and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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The strongest genetic risk factor for Alzheimer's disease (AD) is the Apolipoprotein E type 4 allele (ApoE ε4). The interaction between sex and ApoE ε4 carrier status on AD risk remains an area of intense investigation. We hypothesized that sex modulates the relationship between ApoE ε4 carrier status and brain tau deposition (a quantitative endophenotype in AD) in individuals with mild cognitive impairment (MCI). Methods : Preprocessed 18 F-AV-1451 tau and 18 F-AV-45 amyloid PET images, T1-weighted structural magnetic resonance imaging (MRI) scans, demographic information, and cerebrospinal fluid (CSF) total tau (t-tau) and phosphorylated tau (p-tau) measurements from 108 MCI subjects in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were included. After downloading pre-processed images from ADNI, an iterative reblurred Van Cittertiteration partial volume correction (PVC) method was applied to all PET images. MRIs were used for PET spatial normalization. Regions of interest (ROIs) were defined in standard space, and standardized uptake value ratio (SUVR) images relative to cerebellum were computed. ApoE ε4 by sex interaction analyses on 18 F-AV-1451 and CSF tau (t-tau, p-tau) were assessed using generalized linear models. The association between 18 F-AV-1451 SUVR and CSF tau (t-tau, p-tau) was assessed. Results : After applying PVC and controlling for age, education level and global cortical 18 F-AV-45 SUVR, we found that the entorhinal cortex, amygdala, parahippocampal gyrus, posterior cingulate, and occipital ROIs exhibited a significant ApoE ε4 by sex interaction effect (false discovery rate P < 0.1) among MCI individuals. We also found a significant ApoE ε4 by sex interaction effect on CSF t-tau and p-tau. 18 F-AV-1451 SUVR in the 5 ROIs with ApoE ε4 by sex interaction was significantly correlated with CSF p-tau and t-tau. Conclusions : Our findings suggest that women are more susceptible to ApoE ε4-associated accumulation of neurofibrillary tangles in MCI compared to males. Both CSF tau (p-tau, t-tau) and brain tau PET are robust quantitative biomarkers for studying ApoE ε4 by sex effects on brain tau deposition in MCI participants.

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δ-Protocadherins partition the zebrafish optic tectum into radial columns of neurons, and the neurons within a column are siblings derived from common neuronal progenitors.