Eight compounds were isolated from the leaves of Clerodendrum inerme, including one new rearranged abietane diterpene, crolerodendrum B (1). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated. Compounds 1, 3 and 4 exhibited strong DPPH radical-scavenging effects (ED values of 17.6 ± 2.1, 10.1 ± 0.8 and 11.3 ± 0.3 μM, respectively) and 4 showed strong cytotoxicity against the HCT116 cell line (IC = 3.46 ± 0.01 μM).

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Five new dibenzocyclooctadiene lignans isolated from the stems of Kadsura induta. Their anti-inflammatory activities were studied by molecular docking and inhibition of NO production in LPS activated-RAW264.7 cells.

Key words Acanthaster planci; starfish; pyrrole oligoglycoside; isolation; nitric oxide (NO) productionStarfish are benthic widely distributed marine invertebrates found from shallow to deep waters in all the oceans. Starfish have attracted organic chemists, biochemists, and pharmacologists as a fascinating source of bioactive secondary metabolites mainly steroidal and ceramide derivatives. 1-3)Of these, the crown-of-thorns starfish, Acanthaster planci is found throughout the tropical Indo-Pacific region being one of the largest starfish in the world. The adult A. planci is a carnivorous predator that feeds exclusively on coral polyps and is largely responsible for the damage inflicted on the Great Barrier Reef. Steroid and ceramide glycosides are main constituents of this starfish. 3,4)Our previous studies yielded several steroid glycosides from A. planci. [5][6][7] In continuation of our investigations on this species, the current paper deals with the isolation and structure elucidation of two new pyrrole oligoglycosides namely plancipyrrosides A and B (1 and 2, Fig. 1). Their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were also evaluated. Results and DiscussionUsing various chromatographic procedures, two new pyrrole oligoglycosides were isolated from methanol extract of the Vietnamese starfish A. planci. Plancipyrroside A (1), isolated as a colorless powder revealed a quasi-molecular ion peak at m/z 696.2715 [M+H] +

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