This study investigates the impact of HEdPERF on students' satisfaction and academic performance in Ghanaian private universities, with students' attitude towards learning as a mediator. The study was conducted on a total of 600 students selected from 6 private universities in Ghana out of which 421 responses received were useable representing 70.16% response rate. Purposive and convenience sampling techniques were adopted in selecting respondents. Questionnaire was used to collect data. Explanatory research design was also used. Stata version 13 and IBM Statistical Package for Social Sciences version 20 were the software used in data analysis. The study made use of Structural Equation Model (SEM) for data analysis and explored direct, indirect and total effect relationships. Confirmatory Factor Analysis (CFA) was used for data purification. The research found that HEdPERF has positive and statistical significant relationships with students' satisfaction, attitude towards learning and academic performance. Attitude towards learning also has positive and statistical significant relationship with students' satisfaction and academic performance. As regards the mediation effect, attitude towards learning partially mediates between HEdPERF on one hand, and students' satisfaction and academic performance on the other. This means that managers of Private Universities should consider service quality effects on students' satisfaction and academic performance with and without attitude towards learning in their strategic management.