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Bacillus cereus is a rare but highly virulent bacterial pathogen in neonatal medicine, associated with a high mortality rate. We report on the clinical presentation of two infants, one extremely preterm and one term born neonate, who developed severe B. cereus infection. In both both cases, only the combination of potent second line antibiotics and the removal of all central catheters led to the clinical stabilisation of the patient and to a successful eradication of the pathogen.

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