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Though the renin content of a kidney is stated to be reduced by denervation and steroids (as in kidney allotransplantation presumably) there appears (in a large proportion of rejection episodes) little interference with the mechanism which allows hypertensive states to be reached. So far as I can determine by experiment, the role of renin in renal failure remains an interesting speculation lacking direct evidence in its support. There is, however, some direct evidence against its primary involvement.-I am, etc., W. J. DEMPSTER.