Elephantopus mollis and Elephantopus scaber were collected from Bay Nui region (An Giang province) for three years (2016)(2017)(2018)(2019). Their morphological characteristics, anatomical structures and medicinal powder were analyzed and compared with purpose of supplementing data to Elephantopus genus in Vietnam. The results showed that the morphological similarities of these two species occur at the sapling stage. At the mature stage, E. scaber has underground stem, purple flowers, and E. mollis has aerial stem, white flowers. In addition, these two species are able to be distinguished based on the size, thickness, tips shape or color of all leaves. The anatomical characteristics and the structure of the medicinal powder also showed differences in number and arrangement of xylem, and in covering trichomes of the two species at two stages (sapling and adult stages). Some byproducts such as calcium oxalate crystals, essential oil-secreting cells and inulin crystals were found in the vegetative organs of E. mollis and E. scaber collected from An Giang province.

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