Introduction: Knowledge and attitude regarding pain management is one of the factors with the highest predictive value and it can explain 69% of nurses' s pain management practice [2]. Therefore, a standard tool to measure the pain management knowledge and attitude of nurses in Vietnam is needed. Objective: Testing the validity and reliability of the Knowledge and attitudes survey regarding pain tool Vietnamese version (KASRP -V), so as to measure the nurse's pain management knowledge level in Vietnam Method: The psychometric properties testing of KASRP tool Vietnamese version has undergone a strict standardization process including testing for content validity, discriminant validity, test-retest reliability, internal consistency reliability. 6 experts assessed the content validity. 50 nurses and 73 nursing students were selected to collect data for the discriminant validity testing. Thirty nurses out of 50 nurses were selected to collect data for the internal consistency reliability and test-retest reliability testing. Results:The KASRP tool Vietnamese version includes 41 items, the CVI index for each item ranged from 0.83-1, S-CVI=0.996. The discriminant validity was verified because there was a difference in knowledge scores between the group of nurses with experience in patient care and the group of 4th years nursing students (Z=-2.256, p=0.01).. Internal consistency reliability was measured by Cronbach alpha score. The Cronbach alpha value of each item ranged from 0.885 - 0.887 and the total score was 0.888. The correlation coefficient between each item with the total ranged from 0.300 - 0.446. The ICC score = 0.977 (with 95% CI=0.631-0.994, p = .000) was measured to assess test-retest reliability Conclusion: This evaluation of the KASRP -V demonstrated acceptable validity and reliability Article Details

Objectives: Interferon-stimulated gene 20 (ISG20) plays an important role in viral infection and cancers. This study investigated the association between ISG20 rs4566136 polymorphism with HBV-related hepatocellular carcinoma (HCC). Subjects and methods: The SNP ISG20 rs4566136 was genotyped by Sanger sequencing in 115 patients with HCC, 100 liver cirrhosis patients (LC) and 120 healthy controls (HC). Results: We observed that the frequencies of genotype ISG20 rs4566136CC and allele rs4566136C were significantly lower in HCC patients compared to LC patients and HC individuals. These results indicated that the SNP ISG20 rs4566136 was associated with HCC (HCC vs. LC: OR (95%CI) = 0.67 (0.46-0.99), p = 0.04; HCC vs. HC: OR (95%CI) = 0.2 (0.12 - 0.32), p < 0.001. Patients with genotype rs4566136TT had higher AST and ALT levels, followed by patients with genotype rs4566136TC and rs4566136CC. However, the difference was not significant. Conclusion: ISG20 rs4566136 polymorphism is associated with HBV-related HCC in the Vietnamese population. Allele rs4566136C contributes to a decreased risk of HBV-related HCC. * Keywords: ISG20; SNPs; rs4566136; HBV; HCC.