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A series of four new Schiff base transition metal complexes [Co(II), Ni(II), Cu(II) and Zn(II)] derived from N-(salicylidene)- L-alanine and N,N,N',N'-tetramethylethylene-1,2-diamine (tmen) were designed, synthesized and tested for larvicidal activity against Culex quinquefasciatus, the southern house mosquito, which is the primary vector of St. Louis encephalitis virus and West Nile virus. All the complexes were characterized by physicochemical and spectral studies such as UV-Visible, FTIR, and EPR. The X-ray crystallographic analysis of Ni(II) complex revealed that, Ni(II) cation is surrounded by nitrogen and oxygen atoms from the Schiff base ligand, the oxygen atom of a water molecule, and two nitrogen atoms from tmen. Intermolecular hydrogen bonding stabilizes the Ni(II) complex. Results indicated that all the complexes exhibited higher mosquito larvicidal activity against C. quinquefasciatus.

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A Schiff base ligand prepared from amino acid (L-Histidine) and salicylaldehyde (L1), 1,10 phenanthroline (L2) and its transition metal complexes of general formula [ML1L2] (where M = Co(II), Cu(II), Zn(II), and Cd(II)) has been synthesized and tested for in vitro antimicrobial study against harmful bacterial strains Escherichia coli (gram negative bacteria), Bacillus subtilis, Staphylococcus aureus (gram positive bacteria), and fungal organisms Aspergillus flavus, Rhizophus stolonifer and Mucor ellipsoideus respectively via agar-well diffusion technique. The larvicidal activity of the complexes was tested against Culex quinquefasciatus mosquito. The synthesized complexes exhibited excellent antioxidant properties both by DPPH and Hydrogen peroxide assays. Analytical and spectroscopic techniques such as UV-Visible, FTIR, SEM, NMR, and HRMS were used to characterize the produced Schiff base metal complexes. TGA-DTA analysis was used to investigate the thermal stability of the complexes. The redox characteristics of the complexes were examined using cyclic voltammetry. Cd(II) complex shows the maximum zone of inhibition values 20 mm and 21 mm for S. aureus, and M. ellipsoideus, respectively. Among the synthesized complexes, Cd(II) complex showed highest antimicrobial, larvicidal activity and very good antioxidant property.