AIMTo analyze the diagnostic value of a circular RNA (circRNA), circ-LDLRAD3, in pancreatic cancer.METHODSExpression levels of circ-LDLRAD3 were tested in both cells and clinical samples; the latter included 30 paired pancreatic cancer tissues and adjacent non-tumorous tissues, 31 plasma samples from patients with pancreatic cancer, and 31 plasma samples from healthy volunteers. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to measure expression levels of circ-LDLRAD3 in cells and clinical samples; then, the relationship between clinicopathological factors of patient samples and expression of circ-LDLRAD3 in pancreatic cancer was analyzed. The diagnostic value of circ-LDLRAD3 was verified by receiver operating characteristic (ROC) curve analysis.RESULTSCirc-LDLRAD3 was up-regulated in pancreatic cancer cell lines (P < 0.01), pancreatic cancer tissues (P < 0.01), and plasma samples from patients with pancreatic cancer (P < 0.01). High expression of circ-LDLRAD3 was significantly associated with venous invasion, lymphatic invasion, and metastasis. The area under the ROC curve of circ-LDLRAD3 alone or combination with CA19-9 was 0.67 and 0.87, respectively, with a sensitivity and specificity of 0.5738 (alone) and 0.7049 (alone), and 0.8033 (combination) and 0.9355 (combination), respectively.CONCLUSIONThese data suggest that circ-LDLRAD3 may be a biomarker in the diagnosis of pancreatic cancer.

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Background:Tic disorders (TD) are common neuropsychiatric disorders among children and adolescents. Still, there is great uncertainty regarding their epidemiology in China. We aim to depict the prevalence of TD for children in China and explore the influence of sex, age, geographic distribution, and diagnostic criteria on the prevalence rates.Methods:We searched PubMed, EMBASE, four Chinese electronic databases, and relevant lists. Two reviewers independently selected trials, assessed trial quality, and extracted the data.Results:We included 13 studies investigating 269,571 participants. The sample size ranged from 563 to 216,005 participants. The age of participants ranged from 3 to 16 years. The meta-analysis of the prevalence of TD was 6.1% [95% CI: 0.036–0.100, I2 = 49.7%]. The prevalence of transient tic disorder (TTD), chronic tic disorder (CTD), and Tourette syndrome (TS) was 1.7% [95% CI = 0.009–0.031, I2 = 49%], 1.2% [95% CI = 0.007–0.022, I2 = 48.3%], and 0.3% [95% CI = 0.001–0.008, I2 = 49.5%], respectively. The prevalence of TD in boys [5.1%, 95% CI = 0.026–0.098, I2 = 49.3%] was higher than that in girls [2.4%, 95% CI = 0.009–0.065, I2 = 49.4%]. The prevalence of TD in urban area [2.6%, 95% CI = 0.019–0.034, I2 = 35.5%] was higher than that in rural area [2.2%, 95% CI = 0.016–0.030, I2 = 33.9%]. The prevalence of TD in central China [10.7%, 95% CI = 0.043–0.242, I2 = 49.2%] was higher than that in North China [7.8%, 95% CI = 0.007–0.522, I2 = 49.9%] and East China [4.4%, 95% CI = 0.015–0.120, I2 = 49.8%].Conclusion:TD is a common disease in China, with prevalence differing based on sex, age, and region.

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