Objectives: To detect the expressions of hypoxia-inducible factor 1α (HIF-1α) and microRNA-210 (miR-210) in the aqueous humor of patients with central retinal vein occlusion (CRVO) combined with macular edema, and explore their correlations with CRVO combined with macular edema. Methods: A total of 65 patients (65 eyes) with CRVO combined with macular edema who were treated in the Lixiang Eye Hospital of Soochow University from April 2018 to March 2020 were selected as subjects (CRVO combined with macular edema group). Additionally, 74 patients (74 eyes) with cataract were selected during the same period as cataract control group. The expressions of HIF-1α mRNA and miR-210 in the aqueous humor were detected by quantitative real-time PCR (qRT-PCR). The levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in the aqueous humor were measured using enzyme-linked immunosorbent assay (ELISA). The correlations of HIF-1α mRNA and miR-210 in the aqueous humor of patients with CRVO combined with macular edema with vasoactive molecule levels, the diagnostic value of HIF-1α mRNA and miR-210 levels in the aqueous humor in CRVO combined with macular edema, as well as the factors influencing the occurrence of CRVO combined with macular edema were analyzed. Results: The levels of HIF-1α mRNA, miR-210, MCP-1, VEGF and IL-6 in the aqueous humor of the CRVO combined with macular edema group were higher than those of the cataract control group (P < 0.05). In the CRVO combined with macular edema group, HIF-1α mRNA and miR-210 levels in the aqueous humor were positively correlated (r = 0.522, P < 0.05), and they were positively correlated with MCP-1, VEGF and IL-6 levels (P < 0.05). The area under the curve (AUC) of HIF-1α mRNA and miR-210 in the aqueous humor in diagnosing CRVO combined with macular edema was 0.888 and 0.866, the specificity was 95.9% and 85.1%, and the sensitivity was 76.9% and 80.0%, respectively. The AUC of their combination was 0.937, with the specificity of 93.2% and the sensitivity of 86.2%. HIF-1α, miR-210 and VEGF were the independent risk factors affecting the occurrence of CRVO combined with macular edema (P < 0.05). Conclusion: In patients with CRVO combined with macular edema, HIF-1α mRNA and miR-210 were highly expressed in the aqueous humor, which may play an important role in the occurrence and development of the disease. doi: https://doi.org/10.12669/pjms.38.5.5092 How to cite this:Hu P, Liu G, Sun H, Wei W. Expressions of HIF-1α and MiR-210 in aqueous humor of patients with central retinal vein occlusion combined with macular edema. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5092 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract-A new scheme is proposed to solve the practical problems in the intelligent monitoring of 220kV substation equipment. By analyzing the changes in temperature of substation electrical equipment, it applies wireless sensor network technology in the inverter station based on the running condition of the equipment. In addition, the acquisition, processing, and communication of temperature information is used as the major research object, and a kind of intelligent monitoring of substation equipment system based on wireless sensor network is designed. By using C805IF996 chip and nRF905 chip as the main chips, the hardware and software design of the temperature data acquisition node and sink node are realized. The result show that the electrical equipment based on wireless sensor has a great impact in overheating monitoring. Based on the above finding, a conclusion is drawn that wireless sensor provides an effective solution for the application of intelligent monitoring of electrical equipment.Keywords-wireless sensor, temperature monitoring, acquisition node, sink node IntroductionFor high voltage electrical equipment in substation, it is easy to appear insulation aging or too large contacted resistance phenomenon during the long time of operation, and it will lead to overheating, cause fires and large scale blackouts, and bring about significant economic losses. Since that a large proportion of the temperature change of substation high voltage electrical equipment can reflect the running state of the equipment, it is of practical value for make a real-time temperature monitoring on the substation equipment [1]. Along with the continuous development of computer technology, wireless communication and sensor technology, wireless sensor network (Wireless Sensor Network, WSN) with the integration of sensor technology, information processing technology and wireless communication technology comes into being. This paper applies the wireless sensor network technology in the inverter staiJOE -Vol. 13, No. 7, 2017 25

With the increasing development of electronic computers and the popularization of computer technology, management systems have been widely used in the society. With the continuous improvement of the teaching system, the methods of education and teaching are also quietly changing, especially in the field of higher vocational education. Due to the characteristics of vocational education, it makes “training project progress control” and “teaching resource integration” the teaching requirements of “distribution,” “strictly restricting daily work habits,” “improving professional quality,” and “teachers’ effective control of the quality of students’ personal projects” that have become increasingly urgent needs in vocational colleges. There is a certain gap between the standards and quality of talent training in our country’s applied undergraduate colleges, and the society’s requirements for high-skilled talents and practical teaching in applied undergraduate colleges are a necessary condition for cultivating high-skilled talent. This subject research takes the mechanical manufacturing professional practice teaching system as the research object, conducts in-depth investigation and research in applied undergraduate colleges, explores the status quo of the mechanical manufacturing professional practice teaching system of applied undergraduate colleges, and analyzes the reasons for the problems. In this study, six classes of mechanical manufacturing majors in six applied undergraduate colleges were selected as the experimental group and the control group for comparison. The experimental group adopts an embedded mechanical manufacturing professional teaching system based on deep learning. In daily teaching, the control group used traditional teaching methods to learn. The questionnaire understands the role of the embedded machinery manufacturing professional teaching system in teaching from four aspects: practical teaching curriculum, practical teaching content, practical teaching equipment, and practical teaching teachers. Experiments have proved that more than half of the people think that the teaching effect of the current mechanical manufacturing professional practice teaching courses is average; only 17.18% think that the classroom is good, and 24.36% think that the classroom is poor. This shows that the construction of similar engineering professional practice is in line with the major itself, and the teaching system has theoretical guiding significance, which is conducive to the seamless connection of mechanical manufacturing majors and industrial positions in applied undergraduate colleges; it is conducive to continuously improving the core competitiveness of mechanical manufacturing majors in industrial and applied undergraduate colleges.