Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst is a popular medicinal mushroom. Scientific reports had shown that the wound healing effects of G. lucidum were partly attributed to its rich polysaccharides. However, little attention has been paid to its potential effects on wounds associated with diabetes mellitus. In this study, we evaluated the wound healing activity of the hot aqueous extract of G. lucidum in streptozotocin-induced diabetic rats. The extract of G. lucidum was standardised based on chemical contents (w/w) of total polysaccharides (25.1%), ganoderic acid A (0.45%), and adenosine (0.069%). Six groups of six rats were experimentally wounded in the posterior neck region. Intrasite gel was used as a positive control and aqueous cream as the placebo. Topical application with 10% (w/w) of mushroom extract-incorporated aqueous cream was more effective than that with Intrasite gel in terms of wound closure. The antioxidant activity in serum of rats treated with aqueous extract of G. lucidum was significantly higher; whereas the oxidative protein products and lipid damage were lower when compared to those of the controls. These findings strongly support the beneficial effects of standardised aqueous extract of G. lucidum in accelerating wound healing in streptozotocin-induced diabetic rats.
Mushrooms have been identified as one of the high-value commodities under Malaysia's National Agro-Food Policy (2011-2020). Development of the mushroom industry emphasizes on further area expansion, increased productivity, development of new varieties and product quality improvement. At present, three medicinal mushroom varieties, namely the Hericium erinaceus (Bull.: Fr.) Pers., Lignosus rhinocerotis (Cooke) Ryvarden and Ganoderma lucidum (Curtis) P. Karst. are developed as nutriceutical products in Malaysia Hericium erinaceus, also known as Lion's mane, Monkey's head, Hedgehog mushroom, Sa tyr's beard, Pom pom blanc, Igelstachelbart, and Yamabushitake is distributed in Asia, Europe and North America. It is a temperate mushroom that requires cool temperatures of 18 °C to 24 °C to produce fruiting bodies. Since 2000, it has been domesticated via adaptation to tropical climate in Malaysia. A standardized aqueous extract from fruiting bodies that contains approximately 21% β-(1-3), (1-6)-glucans and 0.2% adenosine was marketed as NevGro TM by Ganofarm R&D Sdn Bhd. The mushroom has been extensively tested in in vitro trials in our laboratories using neuronal cell lines, as the neurite outgrowth stimulator in the cultured cells of neural hybrid clone NG108-15 and PC12, and as the regulator of oxidative stress in the dermal fibroblasts of Friedreich's ataxia patients. Further, we explored the ability of locally cultivated H. erinaceus in the enhancement of peripheral nerve regeneration and acceleration of motor functional recovery after crush injury. Upregulation of signaling pathways as well as axonal protein synthesis and degradation are consistent with the beginning of motor functional recovery of injured limb. 2
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