No abstract

This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts).

No abstract

Systemic deficiency of vitamin D and silicon compounds in the human body leads to numerous negative consequences, primarily in the field of the functioning of the musculoskeletal system: even in the absence of a lack of calcium and phosphorus compounds, which are considered to be the main bone-forming substances, bone mineralization substances, the likelihood of falls and fractures increases, muscle pain occurs. Based on the known mechanisms of the physiological action of vitamin D and silicon on the human body, it was assumed in this work that a food supplement containing cholecalciferol and water-soluble chelated forms of silicon will have a synergistic effect. It was shown that using solid-phase mechanochemical treatment in the optimal mode, a product containing water-soluble chelated silicon compounds with an equilibrium concentration of up to 24 mg / l is obtained from rice husks and green tea. The optimal mode, characterized by high resistance to instabilities of the technological process, obtaining a product containing chelated silicon compounds from rice husk and green tea, is the rotor speed of the RM-50 semi-industrial centrifugal roller mill-activator equal to 1200 rpm at a feed rate of processing area equal to 43 kg / h. The resulting prototype was used as a solid matrix - the basis for applying cholecalciferol and obtaining a biologically active food supplement. The calculated amounts of the supplement required for consumption to replenish the body's daily need for vitamin D have shown the advisability of using soluble gelatin capsules.