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Supporting people’s culture, income and healthcare, medicinal plants are of a great importance in Himalayas. Trading these herbal formulations worldwide is earning billions. But since the demand of such splendid plant and plant products has tremendously hiked in past two decades, and because of the unstable environmental changes due to global warming and industrialisation, these significant species are in threat of extinction. To preserve these treasures, several technical steps have been adopted by the government. A successful establishment of plants sector will raise rural empowerment, boost international commerce and contribute to health of millions worldwide. Alongside highlighting the major medicinal plant species and their uses, this review also foregrounds traditional medicinal practitioners, regions of trans-Himalayas rich in medicinal plants, major threats to these plants, significant biomolecules and detection techniques, threats to these plants, and government bodies and their responsibilities for their conservation.