An efficient domino approach has been developed for the synthesis of polyheterocyclic derivatives constituting pyrrole moiety. Lewis acid catalyzed reaction of 2‐substituted‐2‐hydroxy‐indane‐1,3‐diones and 1,4‐benzoxazinone derivatives resulted in the formation of polyheterocyclic compounds under metal‐free and mild conditions in good to excellent yield. The reaction is highly regioselective for C−C and C−N bond construction proceeded via intramolecular [3+2] cycloaddition reaction. The protocol is highly efficient, obviates column chromatography and the products are obtained by simple filtration followed by washing with solvent.

A base-catalyzed novel [3 + 2] cycloaddition reaction between arylidene-1-phenyl succinimides and alkylidene acenaphthylenones is carried out to access succinimide substituted spiro[acenaphthylenone-cyclopentane]fused scaffolds with high regio-and stereo-selectivity under mild conditions. The reaction of alkylidene acenaphthylenones with 1,4-benzoxazinone deriv-atives under the influence of environmentally benign iodine afforded polyheterocyclic compounds embedded with pyrrole moiety. This metal-free synthesis is highly efficient and atom economic and the protocol obviates column chromatography. The products are isolated by simple decantation followed by washing with solvent.

Corona virus positive sense Ribonucleotide Acid virus with spike like structure as well as a zoonotic virus causing number of diseases in pigs, cows, chickens and recently in a tiger as well as humans. The worldwide emerging pandemic of a great concern to all the scientists, virologists, microbiologists, doctors and even to the common people. In December2019 a life-threatening virus novel corona virus 2019(2019-nCoV) also called as (SARS-CoV) which is an outbreak emerged from the city of Wuhan in China and spread nation-wise to all the world. The disease caused by SARS-CoV-2 is a corona virus disease COVID-19. SARS-CoV2 like SARS-Corona virus uses receptor ACE2 to their entrance into the host cell. Many drugs like Hydroxy-chloroquine etc. used for the treatment as it decreases the effect of corona virus by inhibiting the replication of the corona virus. SARS-CoV2 spreads faster than their two other ancestral species i.e., SARS (2002) and MERS (2012). This virus is spreading exponentially therefore its proper rapid diagnosis is of great concern for the infected ones by providing them medicos. In this review article we will focus on the different diagnostic methods for COVID which are based on molecular and serological testing. RT-PCR the first and rationally used technique to the diagnosis sometimes give false positive and false negative results ascribed to inaccurate isolation of the nucleic acids and takes 5-6 hours which are not applicable for the detection at early stage of infection. So other methods like RT-LAMP (Loop Mediated Isothermal Amplification),FET (Field Effect Transistor)based biosensor detect S-protein on the virus surface, Lateral flow immunoassay (LFI)are the other alternative methods for diagnosis purposes.

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