No abstract

Sickle cell disease is the most common inherited hemoglobinopathy associated with adverse maternal and fetal outcomes. It is often diagnosed at an early age. Presentation for the first time in pregnancy as leucoerythroblastosis is rare. Diagnosis requires a strong suspicion with the demonstration of hemoglobin S in blood.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) infusion has been reported with the development of transient maculopapular rash with spontaneous resolution. A 54-year-old Indian female developed intense erythematous generalised rash involving the face, trunk, extremities, palms and soles following GM-CSF infusion. Focal exudation and purpura were seen. Infusion was stopped and she was managed with a short course of systemic steroids. As yet, the development of such an atypical, severe rash following this cytokine infusion has not been reported in the literature.