All the skin diseases in Ayurveda have been described under the heading of 'Kushta', which are further divided into Maha Kushtaand Kshudra Kushta. Kushta is a chronic disease that has substantial psychological and social impact on a patient's life. However the treatment options available in contemporary system of medicine are not much satisfactory. Therefore by screening of Kushtaghna dravyas from Bhavprakash Nighantu can give effective solutions for Kushta Chikitsa. The literary screening concluded that there are about 98 dravya (Herbal and Metal) are recommended as Kushtaghna, but their specific action is not defined on the basis of their Rasapanchaka. A literary review of the rasa panchaka is done to assess their probable mode of action. Samprapti of Kushta shows tridosha dushti (Vata and Kapha pradhana) and dushya are twak, lasika, shonita and mamsa predominantly, so the line of the treatment should be ushna, tikshna, Vata Kapha Shamaka, Rakta Prasadana mainly. The present paper is about to enlist the Kushtaghna herbal and metal dravyas mentioned in Bhavprakash Nighantu with their Rasa, Veerya and Vipaka, Guna and karmas for critical analysis, to assess their specific type Kushtaghna property.