Complexes of chromium(III) metal ion with schiff base i.

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Manganese and cobalt complexes have been designed and prepared with a tetradentate ligand i.e. isopthalic acid-bis(thiosemicarbozone) (IPBT), which bind to metal ions via donor atoms present in ligand. Different spectroscopic techniques viz. nuclear magnetic resonance, infra red, mass, electronic spin resonance and analytical studies have been used to determine the chemical composition of synthesized IPBT and its Mn(II) and Co(II) complexes. The spectroscopic data exposed that IPBT behaves in a tetradentate (N2S2) mode by having ability to bind with metal ions through N2S2 atoms. An octahedral structure for manganese and cobalt complexes has been suggested on the basis of spectroscopic as well as analytical studies. The ligand (IPBT) and its metal(II) complexes have been screened to determine their antipathogenic activity against some selective microorganisms S. aureus, P. aeruginosa, E. coli, A. niger, M. phasolina and P. glomerata. In this experimental work, well diffusion and poisoned food techniques have been introduced for screening purpose and as standard drugs neomycin and chlorothalonil have been used. Data for antipathogenic screening exposed that metal complexes exerted higher activity towards all examined microbes (bacteria and fungi) even than ligand.

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A synthetic approach has been designed and followed for the synthesis of new bidentate Schiff base ligand 2-acetylthiophenenicotinic hydrazone (L) (which possessed nitrogen and oxygen donor atoms) and its Co(II) and Cu(II) mononuclear complexes. All the compounds were examined IR, 1H NMR, mass, EPR, conductivity, elemental analysis, etc. Octahedral geometry has been assigned to all synthesized compounds on the basis of magnetic, IR and electronic spectral analysis. In vitro activity i.e. antibacterial (E. coli and P. aeruginosa) and antifungal (A. niger, M. phasolina and P. glomerata) had been examined for these compounds following well diffusion and poisoned food methods, respectively. During the performance of antifungal activity, antifungal agent was incorporated into the molten agar at various concentrations and mixed well. After performance of in vitro activity, it has been resulted out that metal(II) complexes exhibited remarkable activity than free ligand but less active compared to the standard drugs..