There was a significant increase in salivary flow rate from baseline after starting clozapine, with a significant increase from the second to the third week followed by a "plateau."

The study of quality of life and subjective wellbeing of patient is a recent phenomenon which has gained attention only in last two decades. Less attention was given to treating long term impairement and chronic illness. Rather cure was given more importance. However, this trend has changed, and it has shifted to the concept of quality of life. Now the goal of treatment is to give the patient good quality of life, this becomes more important in cases where cure is impossible or there is long term impairements due to illness.