Thresholding is a prerequisite for many computer vision algorithms. By suppressing the background in an image, one can remove unnecessary information and shift one’s focus to the object of inspection. We propose a two-stage histogram-based background suppression technique based on the chromaticity of the image pixels. The method is unsupervised, fully automated, and does not need any training or ground-truth data. The performance of the proposed method was evaluated using a printed circuit assembly (PCA) board dataset and the University of Waterloo skin cancer dataset. Accurately performing background suppression in PCA boards facilitates the inspection of digital images with small objects of interest, such as text or microcontrollers on a PCA board. The segmentation of skin cancer lesions will help doctors to automate skin cancer detection. The results showed a clear and robust background–foreground separation across various sample images under different camera or lighting conditions, which the naked implementation of existing state-of-the-art thresholding methods could not achieve.