Ficus pumila Linn. has been reported to be rich in phenols, hepatoprotective and antiproliferative on leukemic cancer cells. The aim of this study was to evaluate the nephroprotective effect of hydroethanolic leaves extracts of F. pumila on gentamicin-induced kidney damage in rats. Twentyseven female Wistar albino rats were divided into 9 groups (n=3). Group 1 being normal; group 2 was the gentamicin (GM) induced only (80 mg/kg b/w ip for 5 days); groups 3, 4, & 5 rats were treated with gentamicin (80mg/kg b/w ip for 5 days) and F. pumila extract at 100, 250, and 500 mg/kg b/w orally respectively; groups 6, 7 & 8 rats received the extract only (100, 250, and 500 mg/kg b/w orally) respectively and group 9 being gentamicin and silymarin (100 mg/kg b/w orally) for 21 days. Blood samples were taken 24 hrs after the experimented period and biochemical and haematological parameters were analyzed. GM nephrotoxicity was characterized by significantly Original Research Article