ZIKV (Zika virus) is first major infectious disease related to human birth defects. ZIKV is flavivirus, family Flaviviridae causally associated with Guillain-Barre´ Syndrome, fetal microcephaly and other birth defects. Zika virus diseases discovered about 69 years ago and it remains in relative obscurity, within the span of two years it introduced in Brazil, Latin America and spared rapidly in Asia, USA, Europe and Australia. Detection methods are potentially increases which is positive sign to diagnosis of ZIKV disease and development of vaccine. Sexual transmission of Zika in to male-to-female and maleto-male is documented. There is no conformed vaccination or particular Treatment. In the review, we discussed current epidemiology, virology studies, Diagnosis and Treatment and link between nervous system disorders.