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Busch Campus, P. 0. Box 789 Piscataway, New J e r s e y 08854 ABSTRACT A mathematical model was developed t o c o r r e l a t e t h e d r u g permeation r a t e t h r o u g h t h e s k i n w i t h t h e d r u g r e l e a s e r a t e f r o m a m a t r i x -t y p e d r u g d e l i v e r y system. Experiments were c a r r i e d 1213 Copyright 0 1985 by Marcel Dekker, Inc. 0363-9045/85/ 1 106-1 2 13$3.50/0 Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Auckland on 11/03/14 For personal use only. 1214 KESHARY, HUANG, AND CHIEN Results indicated t h a t the stratum corneum plays a significant rate-limiting role in the skin permeation of nitroglycerin across the intact skin, yielding a constant skin permeation profile. The permeation rate across the intact skin was observed t o increase with the increase in the drug release flux i n i t i a l l y and then levelled off in a hyperbolic fashion. Various constants were obtained from the reciprocal p l o t of skin permeation rate vs. d r u g release flux. These constants could be used for the prediction of the skin permeation rate. A very good correlation between the predicted and the observed values of skin permeation rates was observed.After the stratum corneum was removed by stripping technique, the mechanism and the rate of skin permeation became dominated by the mechanism and the release rate of the delivery system. A linear correlation was observed between the drug permeation rate through the skin and the equilibrium concentration of d r u g in the skin. This correlation was observed i n b o t h intact and viable skins. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Auckland on 11/03/14 For personal use only.( 1 4 ) .Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Auckland on 11/03/14For personal use only.Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Auckland on 11/03/14For personal use only.