Objective Obesity is a common disorder in our country. Most widely used method to gauge obesity is Body Mass Index (BMI) which is equal to weight in kilogram divided by height in meter square. The objective of our study was to find the levels of liver enzymes ALT, AST & GGT in two groups (overweight individuals and obese individuals). Methods: A total no of 156 individuals were selected for the study and they were categorized into three groups on the basis of BMI- Group I Normal, BMI 18.5 to 24.9 (n=72), Group II Overweight, BMI 25.0 to 29.9 (n=39) and Group III Obese, BMI >30 (n=45). Serum ALT, AST & GGT were estimated by Accurex AC 112 plus semi auto analyser and values were given in U/L. Results: Values of ALT, AST & GGT were with in the normal references range in all the three groups. Conclusion: No significant relation was found between ALT, AST & GGT in normal, overweight and obese individuals. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10147 Asian Journal of Medical Sciences Vol.6(1) 2015 40-42

Objective: The objective of our study was to find out whether vitamin E and vitamins C levels in saliva can be used as a marker for cancer.      

Material and Methods: This study was carried out in the dental OPD of Saraswathi Institute of Medical Sciences, Hapur, U.P.  The saliva was collected from all the subjects. Results were compared with age, sex and matched with controls. Total 20 people were selected in which 10 normal subjects and 10 oral pre cancerous patients. Saliva was estimated for lipid peroxidation (malondialdehyde MDA), Vitamin E and C levels respectively.   

Results: Our results indicated significant increase in lipid peroxidation (MDA) in oral precancerous stages but there was decrease in vitamin E and C levels. This suggests that there is an increase oxidative stress in oral precancerous lesion and may further increase in cancerous stages.   

Conclusion: Free radical induced lipid peroxidation causes a loss of cell homeostasis by modifying the structure and functions of cell membrane. Their chief dangers come from damage they can do when they react with important cellular components such as DNA or the cell membrane. To prevent free radical damage body has a defense system of anti oxidants which are involved in the prevention of cellular damage – the common pathway for cancer ageing and a variety of diseases.

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