Application of drug by topical route is an alternate route for the treatment of skin diseases for systemic route. The skin diseases can be treated by administration of drug by local application and may avoid first pass metabolism. It minimizes systemic side effects and when applied locally can be removed easily if any side effects occur like, irritation, skin rash, redness at the application site. The topical drug delivery has been beneficial for longer period of time because of availability of large surface area of skin which exposed to circulatory routes. Because of this route, one can be directly applied to any external body surface and it is only for local application. Amongst many types of topical dosage form delivery, gel is most likely to be used and is a patient-friendly dosage form. Due to the lack of insoluble excipients and oily bases, the gel represents better release of drug as compared to other topical drug delivery system. Nowadays, many industries follow QbD (Quality by Design) approach for the formulation of Gel to prepare a quality medicine delivery to patients. The QbD approach describes the CQA, CMA and CPP of the formulation which ensures the quality of dosage form. This review article focuses on the different dosage forms, types of gel, evaluation by taking parameters such as drug content, pH, spreadability, extrudability, viscosity, swelling index and in-vitro drug diffusion and application of QbD approach to gel formulation.
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