Background: Usually, the fracture of the medial malleolus is seen through supination-adduction loading of the talus on the articular surface which is mostly a vertical shear fracture. This fracture is managed with various methods including open reduction and internal fixation and antiglide plating. Aim: The present study was done to evaluate the functional and radiological outcomes following open reduction and internal fixation using antiglde plates in vertical shear medial malleolus fracture. Methods: This present prospective clinical study included 44 subjects with vertical shear medial malleolus fracture managed with the antiglide plates. In all subjects clinical and radiographic evaluation was done, tenderness, and union time were assessed at follow-up at 1, 2, and 6 months. Results: The mean union time was found to be 12.29±1.96 weeks. Tempo loss was reported in 27.2% (n=12) study subjects and work remained similar to the pre-surgery work in 72.7% (n=32) study subjects respectively. Pain while walking on uneven surfaces was reported by 18.1% (n=8) of the study subjects. Molandar scores were 92.93±3.69 in the study subjects with a range of 10 between 86-96. The median was found to be 95 (91.23-95) in the study participants.