Xerophytes are the great fighters due to their amazing abilities to deal with extremely challenging environment. These plants are distinct from other mesophytes in having morphological, anatomical and physiological adaptations. Due to these adaptive modifications the biochemistry of these plants is also unique and they are the vital source of valuable phytochemical contents of a range of uses, especially medicinal utilization. Cactus is one of the most widely distributed plants in the xeric environment and has special characteristics. In this review an attempt is made to provide an all-encompassing account of this plant with special focus to its medicinal properties.