Nanotechnology is an innovative area of science that deals with things smaller than 100 nanometers. The influence of nanotechnology in the cosmetic industry is overwhelming since it can enhance the properties attained by the particles at the nano level which includes color, solubility, etc, and also promotes the bioavailability of API. A plethora of nanomaterials can be employed in cosmetics including organic and inorganic nanoparticles. Unlike orthodox carriers, they facilitate easy penetration of the product into the skin and thereby increasing the stability and allowing a controlled drug release so that they can permeate deeper into the skin and start revitalizing it. Nanomaterials rejuvenate the skin by forming an occlusive barrier to inhibit the loss of water from the skin’s surface and thereby moisturize the skin. Nano-cosmeceuticals are used to provide better protection against UV radiation, facilitate deeper skin penetration, and give long-lasting effects. Although they still have some safety concerns, hence detailed characterization or risk assessments are required to fulfill the standard safety requirements. In this review, an attempt is made to make a brief overview of various nanocosmeceutical skincare and anti-aging products.

Inflammation is a defensive response against invasion by foreign bodies, which need to be treated with safer molecules such as phytomolecules like caffeic acid (CA). This work aimed to formulate and evaluate topical cream with CA-loaded nanostructured lipid carriers (NLCs) for anti-inflammatory action. CA-loaded NLCs were formulated by solvent diffusion method followed by preparation of NLCs loaded cream which was evaluated and characterized for various parameters including in-vitro release behavior and in-vivo acute anti-inflammatory effect in carrageenaninduced rat paw edema wistar rats model. The CA-loaded NLCs showed good results for particle size, polydispersity index (PDI), zeta potential, and encapsulation efficiency, while 0.5% w/w cream had a significant anti-inflammatory effect when tested for the acute study. Furthermore, skin-irritation study was carried out on wistar rats and it was observed that the formulated creams did not produce any signs of irritation, edema, and erythema compared to the positive control group (0.9% v/v formalin group). Therefore, formulated NLCs loaded cream can be used as a safe and efficient acute anti-inflammatory agent and considered an alternative treatment strategy to existing formulations.