Objective:To evaluate the anti-inflammatory effect of the third-generation CCB, lercanidipine.Materials and Methods:The ability of lercanidipine to reduce inflammation in carrageenan-induced paw edema in rats was evaluated, using different doses and its anti-inflammatory effect was compared with that of diclofenac sodium. Mast cell degranulation effect of lercanidipine was also carried out.Results:Lercanidipine produced a significant reduction in the inflammatory paw edema at all doses and at all intervals (P < 0.001). The percentage of reduction in edema was found to be proportionate to the doses of lercanidipine. Lercanidipine also significantly reduced the percentage of propranolol-induced mast cell degranulation.Conclusions:It was found that lercanidipine exerts a positive anti-inflammatory effect in a dose-dependent manner and was superior to diclofenac sodium.

Lockdown during COVID-19 have impact in type 2 diabetes mellitus patients requiring medication and routine physical activity. The stress, development of complications of chronic diseases, locked in experience, fear of dying and loneliness in hospital. All these issues suggest that mental health of the diabetes patient is being affected enormously. In this report, we discussed the experience of three patients with diabetes mellitus and among them two acquired COVID-19 admitted to the COVID ward.

Introduction: Osteoarthritis is one of the most common joint disorders in adult population affecting about 10 % of global population above the age of 60 years. Knee osteoarthritis is an important contributor for global disability among the other osteoarthritis and it contributes for 83% of the global disease burden for osteoarthritis. The symptoms of knee osteoarthritis include pain, stiffness and activity induced swelling. Present study aims to validate the correlation between WOMAC index, a widely used clinical scoring system and radiologically proven osteoarthritis which is graded by Kellgren-Lawrence radiological grading system. Material and Methods: The present study was undertaken in a tertiary care teaching hospital by the Department of Orthopaedics, IGMC & RI, Puducherry. It was a hospital-based cross-sectional study. A sample of 240 respondents was selected based on inclusion criteria. Functional limitation and radiological assessment were done using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren and Lawrence (KL) scoring scale respectively. Observation and Results: The mean age of the study participants was 58.17±8.18. Chi square test was applied to test the correlation between WOMAC scoring and Kellgren-Lawrence radiological grading and found that there was significant correlation (P=0.0001 which was <0.05 and hence statistically significant) between two variables. Conclusion:We conclude that from this study a positive correlation has been established between WOMAC scoring and radiological grading by Kellgren-Lawrence in our institute and further studies are needed to assess the use of WOMAC scoring in preoperative and postoperative follow up of severe arthritis.