Background: Blood transfusion is very common in present era. Now day’s whole blood transfusion is common but also the blood product like red blood cell, white blood cell, platelets, clotting factor, plasma can be done .the aim of study to know the storage related changes in whole blood, packed red blood cell. Subjects and Methods: In our institution we have selected 100 voluntary blood donors sample in blood bank of Teerthankar Mahaveer medical college and research centre, Moradabad up to 12 month. Results: The store blood is Followed up to 35th days .during regular interval 1st, 7th, 14th, 21st, 28th and 35th day, in the blood there is significant change in and all other component in all sample. Conclusion: In the case of storage of blood in blood bank. As the number day of store is more the haematological changes is more significant.