In this study, a series of novel geminal bis 1,2,3-triazoles linked to 2H-furo [2,3-d][1,3]thiazine-2,4,5(1H,6H)-trione (3a-3m) were prepared in one pot)-trione (2) followed by Cu(I)-catalyzed azide-alkyne cycloaddition. The synthesized compounds were further explored for in vitro cytotoxic activity against PC3, A549, MCF-7, and HeLa cell lines and results revealed that the five compounds 3c, 3d, 3g, 3l, and 3m have displayed comparable in vitro cytotoxic activity with the standard drug Etoposide.

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