Type II diabetes formerly known as adult-onset diabetes, is a type of diabetes that is characterized by high blood sugar, insulin resistance, and relative lack of insulin due to obesity, lack of exercise or genetically determined. HbA1c in diabetic patients provides valuable information about the changes occurring in the blood glucose level over last three months. SOD is considered as a first line Defense against ROS, as it is present in almost all cells and it deals with the most hazardous radicals i.e. Superoxide (O2 -). Oxidative stress is in the foreground of diabetes which increases with increase in severity of diabetes, keeping these facts in mind the present study was designed to compare SOD level in type II D.M in Jalgaon district. In the present study, we got inverse correlation (non-significant correlation) in these two parameter. As the levels of HbA1c increases there is decrease in SOD levels which indicates that as the severity of diabetes increases the levels of SOD decreases.