Eosinophilic panniculitis (EP) is characterized by prominent infiltration of subcutaneous fat with eosinophils. The etiology is diverse. This is not a disease but represents a reaction pattern that may occur in a variety of circumstances. The exact pathogenesis of the disease is still unclear. We present the case of a 6-year-old girl child who was diagnosed with EP.

Holi is a festival of colours, traditionally celebrated by greeting others and applying various colours. These colours are synthetic dyes which may have harmful side-effects on the skin and mucocutaneous areas like the conjunctiva and oral mucosa. In India, these colours are prepared on a small scale and lack any quality checks. Here we present a case of a 43 years old female who developed angioedema with urticaria progressing into urticarial vasculitis after playing with the colours in the festival of Holi. This case report highlights the need to put manufacturing of Holi colours under the guidelines of the Food and Drug Cosmetic Act and the Bureau of Indian Standards

Wheat (Triticum aestivum L.) is a staple food crop for the global human population, and thus wheat breeders are consistently working to enhance its yield worldwide. In this study, we utilized a sub-set of Indian wheat mini core germplasm to underpin the genetic architecture for seed shape-associated traits. The wheat mini core subset (125 accessions) was genotyped using 35K SNP array and evaluated for grain shape traits such as grain length (GL), grain width (GW), grain length, width ratio (GLWR), and thousand grain weight (TGW) across the seven different environments (E1, E2, E3, E4, E5, E5, E6, and E7). Marker-trait associations were determined using a multi-locus random-SNP-effect Mixed Linear Model (mrMLM) program. A total of 160 non-redundant quantitative trait nucleotides (QTNs) were identified for four grain shape traits using two or more GWAS models. Among these 160 QTNs, 27, 36, 38, and 35 QTNs were associated for GL, GW, GLWR, and TGW respectively while 24 QTNs were associated with more than one trait. Of these 160 QTNs, 73 were detected in two or more environments and were considered reliable QTLs for the respective traits. A total of 135 associated QTNs were annotated and located within the genes, including ABC transporter, Cytochrome450, Thioredoxin_M-type, and hypothetical proteins. Furthermore, the expression pattern of annotated QTNs demonstrated that only 122 were differentially expressed, suggesting these could potentially be related to seed development. The genomic regions/candidate genes for grain size traits identified in the present study represent valuable genomic resources that can potentially be utilized in the markers-assisted breeding programs to develop high-yielding varieties.

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The effects of intermating in F2 generation on mean, genetic variability, heritability and genetic advance in two crosses of wheat (Triticum aestivum L.) (WH 542/WH 1080) and (WH 1105/RAJ 3765//WH 283) were studied. The mean and genetic advance of all the seven characters, viz. days to heading, plant height (cm), number of effective tillers, number of grains/ear, 1000 grain weight (g), biological yield/plant (g), grain yield/plant (g) were increased after first cycle of intermating. Second cycle of intermating further showed its positive impact on mean, genetic variability, heritability and genetic advance. In this study the intermated population produced progenies which out yielded the F2 population indicating the superiority of intermating over the F2 in generating superior performing progenies. The result indicated that the intermated populations are potential candidates for further selection to improve the grain yield in bread wheat and may prove highly useful in generating promising wheat genotypes having desirable quality traits and stress tolerance.