A BSTRACT Context: Oral health knowledge, beliefs, and attitudes of parents have a direct influence on their child’s oral health maintenance, dietary habits, and oral health behaviors. Aim: The aim of this study was to assess the knowledge, and attitude of parents with regard to the oral health practice of their children and its associated factors Material and Methods: A self-administered structured questionnaire was administered to parents or guardians of learners aged 5–12 years at a low socioeconomic rural primary school in the Ugu district, KwaZulu-Natal, South Africa. In addition to demographic variables, knowledge of dental health, use of toothbrush, use of toothpaste, dietary practices, and dental visits; practice with respect to dental care; and attitudes toward oral health were requested. Results: One hundred and forty-four completed survey instruments were received with an 80% (118) representation of mothers. Ninety-five percent of the parents (136) had a positive attitude toward oral health with 86% (124) of the children brushed their tongue and 89% (128) of the children brushed their teeth happily. The mean knowledge score was 70%. Children were significantly more likely to brush their tongues (adjusted odds ratio [AOR]: 3.20 95% confidence interval [CI]: 1.06–9.66 P < 0.001), be happier when brushing their teeth (AOR: 4.65 95% CI: 1.41–15.38 P < 0.001) when the caregivers were their mothers, had an above-average knowledge score (AOR: 1.86 95% CI: 0.72–4.85) and positive attitudes (AOR: 3.20 95%CI: 0.46–22.00). Conclusion: Parents in the rural community have satisfactory knowledge and a positive attitude toward oral health and children display good practices; however, there are a number of gaps noted in overall parental knowledge.