Children with Down syndrome (DS) present with a spectrum of hematolymphoid malignancies ranging from transient myeloproliferative disorder (TMD) which regress spontaneously to frank acute leukemia of both myeloid and lymphoid lineage. Here we present a series of three cases with different manifestation in DS. Three cases of DS presented with TMD, acute myeloid leukemia (AML-M2) and acute megakaryoblastic leukemia (AMKL), respectively. This case series displays the spectrum of hematological manifestations in children with DS. Although TMD and AMKL are strongly associated with DS, other AML subtypes can also be seen in such patients.

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Pathology Section Priavadhana rajan PraSaadSir/Madam, Benign breast lesions are known to occur in pregnancy and in the post partum period, which are related to hormonal changes. Both de novo breast lesions and changes in the pre-existing benign conditions are well known. Lactating adenomas are one such group of tumours that can be diagnosed on cytology.

Tubulo-lobular carcinoma is a rare variant of invasive carcinoma of breast, exhibiting the features of both tubular and lobular component. It accounts for about 1% of mammary carcinomas. Study report a case of 39-year-old female with lump in the left breast for 6 months. Histopathologically it was diagnosed as tubulo-lobular carcinoma of breast. Hence histopathology plays an important role in diagnosis and treatment of mammary carcinomas.