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Introduction: Medical practice rests on the foundation of science. Clinicians are constantly making practical decisions and dealing with situations that demand quick and efficient solutions. The extra ordinary complex functions of the human being depend on the narrow range of the volume and composition of body fluids and electrolytes. These electrolytes run the life with help of meticulously regulated control mechanisms that strictly maintain their levels both extracellularly and intracellularly.1 Materials and methods: This prospective study was conducted over a period of one year and included critically ill children aged 1 month to 12 years admitted to a paediatric tertiary care hospital. Informed consent was obtained from the parents of all the children enrolled in the study. At admission, detailed history was taken and systemic examination was recorded. Venous blood samples were obtained and serum electrolytes were estimated by using Combi line Ion-Selective Electrode (ISE). An Ion-Selective Electrode (ISE), also known as a specific ion electrode (SIE), is a transducer (or sensor) that converts the activity of a specific ion dissolved in a solution into an electrical potential, which can be measured by a voltmeter or pH meter.

Laboratory investigations for any suspected case of solitary plasmacytoma of bone include routine biochemical and hematological investigations along with β2-microglobulin, electrophoresis of serum protein and/or 24-hour urine protein, serum protein immunofixation (IFE), and nephelometric quantification of total immunoglobulin isotype and serum free light chain levels. Bone marrow aspirate and trephine biopsy are mandatory to confirm the absence of clonal plasma cells (for solitary plasmacytoma) or the presence of less than 10% clonal cells (solitary plasmacytoma with minimal bone marrow involvement). Imaging studies such as X-ray, computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT should be used to complement laboratory tests in diagnosis, staging, and defining the local extent of the plasmacytoma. However, guidelines regarding choice of technique for the detection of M band when monitoring a follow-up case of operated plasmacytoma are still not clear. Through this case study, we try to highlight the role of IFE in a follow-up case of operated solitary plasmacytoma of the bone.