Aim: The aim of the study to compare the cyclic fatigue resistance of FlexiCON (Edge Endo) files in rotary versus reciprocating motion in coronal, middle, and apical curvature of the simulated artificial canal. Materials and Methods: A total number of 36 new files, 25 mm length of ISO size 25 at the tip and a taper of 0.06, were used for the study and divided into two groups of 18 files each. Group I: FlexiCON X 3 , was used in a rotary motion and Group II: FlexiCON X 1 was used in a reciprocating motion. Cyclic fatigue testing was conducted in a custom-made device that allowed for a reproducible simulation of a curved canal. The canal system, which comprised two adjustable stainless steel blocks, had a 60° angle of curvature and 3 mm width. The groups were further divided into three subgroups with six files in each, representing apical curvature (Group Ia/IIa), middle curvature (Group Ib/IIb), and Coronal curvature (Group Ic/IIc). Using X-Smart plus motor, files were used in rotary and reciprocating mode and the number of cycles to failure was recorded. Statistical Analysis: Data were analyzed using ANOVA and Post hoc followed by Dunnett's test and unpaired t -test using Statistical Package for the Social Sciences 16 version. Results: FlexiCON X1 reciprocating files showed the maximum cyclic fatigue resistance at coronal curvature (1936.50 ± 1.09) followed by middle (1514.50 ± 1.07) and apical curvature (1487.50 ± 6.75), while FlexiCON X3 rotary files showed the maximum cyclic fatigue at the middle curvature (1106.00 ± 4.21), followed by coronal (920.00 ± 1.16) and apical curvature (757.00 ± 5.34). The statistical analysis revealed a statistically significant difference ( P = 0.001) between the two groups. Conclusion: FlexiCON X1 reciprocating files showed better cyclic fatigue resistance at coronal, middle, and apical curvature compared to FlexiCON X3 rotary files.