Shear walls are effective structural elements used mainly in multi-story buildings to provide resistance against lateral loadings such as earthquake and wind loadings. They have high plane stiffness and strength which can be used to simultaneously resist large horizontal loads while also supporting gravity loads. Hence it is necessary to determine effective and ideal locations of shear walls. Shear wall arrangement must be absolutely accurate, if not, it may cause negative effects instead. A shear wall may contain many openings due to the functional requirements such as doors and windows, which may largely affect the overall seismic response of the structure. In this project, a study has been carried out to determine the effects of combination of shear walls positions and also the optimum structural configuration of multi-storey buildings by providing the shear wall with different openings configuration. This study is carried out on a G+30 story frame shear wall building, with the help of computer application software ETABS, using Response Spectrum method. The comparative results showed that the, time period, top displacement, base shears, story drift and stress distribution around the openings depend on the opening arrangement system.