The key objectives of this study to examine the impact of e-HRM and work from home on employee productivity during COVID-19 among pharmaceutical companies of Sindh, Pakistan. It is difficult for employee to perform at same level due to lockdown and pandemic situation in country. Total 250 employees are considered as sample size. In the present study there are 3 variables and each variable was consisting of 5 items. Due, COVID-19 questionnaire generated via google form and it shared via official e-mail of HR department of respective companies in order to complete the questionnaire. The random sampling techniques applied for in order to chance equal opportunity to be part of this research study. In order to test the proposed hypothesis questionnaire was taken from previous studies. Results revealed that the there is a significant and positive impact of e-HRM and work from home on employee productivity during COVID-19 in Pharmaceutical companies of Sindh, Pakistan. New insights of this study are in past research scholar verified the e-HRM with respect to employee productivity without context of COVID-19 situation and e-HRM and work from home are studied together. The policy makers and top management of Pharmaceutical companies of Sindh, Pakistan should consider these variables for better employee productivity during COVID-19.