The COVID-19 pandemic provides an important reminder that one of the most effective ways to stop the spread of germs and stay healthy is done by one of the simplest Hand washing. The aim of present work was to avoid the adverse effects - itching, irritation, dermatitis etc. An attempt has been made to formulate this poly herbal hand wash by using herbs Neem extract, Ginger extract, Lemon juice, Aloe vera showing range of antimicrobial activity. This proved to be most effective product over Human Hygiene .Different combination of ingredients with plant extracts carried out by soxhlet apparatus method of extraction were tested on skin pathogens Streptococcus Aureus and E.Coli to evaluate the potential of antimicrobial activity by proper zone of inhibition. Ingredients showed significant antimicrobial activity than the commercial ones. Different evaluation parameter i. e physical testing, pH, foaming, viscosity etc. were carrier. The result from the work suggest and support the incorporation and utilization of herbs in formulation to give better synergistic effect. This Polyherbal Hand wash could have great potential for healthy living. So this plant extracts can be used in the preparation of herbal hand wash on commercial scale.