Khaya senegalensis is a well known medicinal plant, widely distributed in Savannah regions and commonly called African mahogany or dry zone mahogany. The plant is known for various medicinal properties in traditional medicinal system and is used to attenuate a variety of diseases. K. senegalensis is reported to contain a variety of bioactive compounds in its different organs including alkaloids, terpenoids, steroids, and phenols. Extensive studies on K. senegalensis revealed its antimicrobial activity, cytotoxicity activity, hepatoprotective activity, antioxidant activity and wound healing activity among several other pharmacological activities. This literature review, based on the multiple researches on K. senegalensis integrated information concerning the phytochemistry and pharmacological activities of the plant which will promote better understanding of the medicinal values, useful to researchers for further study.