The review mainly focuses on the goals to evaluate the clinical and cost effectiveness of neonatal CPAP in a decrease of Mortality, Length of Stay, Respiratory support, Extubation and Intubation. Introduction: Inclusion criteria: This review is conducted in neonates with respiratory failure, Pneumonia sepsis, necrotizing infections, Pneumothorax, Broncho pulmonary distress, respiratory distress syndrome (RDS), COVID-19, and other comorbidities also included. Methods: The databases like PubMed, Google Scholar, and Cochrane were used in this review. Depending on inclusion criteria the full-text articles were assessed and chosen studies were recovered by methodological quality. Results: one twenty-six studies are retrieved which met the inclusion criteria and the extracted studies were pooled statistically and their outcomes were measured. All the studies explain the efficacy of CPAP by reducing Mortality, Length of Stay, Respiratory support, Extubation and Intubation. Conclusion: Currently the evidence states that CPAP reduces Mortality, Length of Stay, Respiratory support, Extubation and Intubation

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The objective of this review was to evaluate the clinical effectiveness of Hyperbaric Oxygen Therapy for various wound conditions in reducing the amputation of diabetic foot ulcer, healing of various wounds, mortality, neurophysiological condition, reduction in ulcers (wound area) and other complications in adults 18 years and over. Introduction: Inclusion criteria: This review included studies conducted among adults with acute traumatic ischemia, carbon monoxide poisoning, central retinal artery occlusion (CRAO), diabetic foot ulcers (DFU), Chronic refractory osteomyelitis, compromised skin graft or flaps (enhancement of healing in selected wounds), crush injuries, cyanide poisoning, decompression sickness, delayed radiation injury, including osteoradionecrosis, soft tissue radiation necrosis, and radiation cystitis, thermal burns, gas or air embolism, gas gangrene (for example, clostridial myositis and myonecrosis) and necrotizing soft-tissue infections. Methods: Databases to be searched include PubMed, Google scholar and Cochrane Following the search, titles and abstracts were screened by two independent reviewers for assessment against the inclusion criteria for the review. The full text of selected citations was assessed in detail against the inclusion criteria, and studies selected for retrieval was assessed by two independent reviewers for methodological validity using JBI critical appraisal tools. Results: The results of the meta-analysis comparing with HBOT compared with standard of wound carewas presented in a forest plot by subgroup analysis and those studies were statistically pooled studies and outcomes were measured. Conclusion: HBOT is a safe procedure for disease treatment and improves different aspects of quality of life in patients. HBOT is a non-invasive, safe treatment while used for different applications. HBOT application reduces the rate of major and minor amputations, and improves the rate of wound healing in nonhealing diabetic ulcers and other diseases. There was statistically significant reduction in amputation and improvement in wound healing and neurophysiological condition.