An epidemiological study of the environmental and genetic factors as well as the possible interplay between them was conducted among 215 patients with Parkinson's disease and 313 controls in a Chinese population in Hong Kong. In univariate analysis, a regular tea drinking habit was found to be a protective factor, which had not been reported before. Smoking (a protective factor), family history, duration of pesticide exposure (in years) in farming and pesticide exposure during farming in women (both risk factors) have been reported previously. In multivariate analysis, current smoking reached borderline significance at the 5% level and the variables, years exposed to pesticides and family history were significant at the 10% level. By contrast with the common occurrence of polymorphism of the CYP2D6 gene (a gene involved with xenobiotic metabolism) in white people, it is very rare in China and is not thought to be a significant factor contributing to Parkinson's disease in Chinese people. (J Neurol Neurosurg Psychiatry 1998;65:781-784)
Super-tough and highly squeezable hydrogel by a one-step polymerization shows ultra extendability and healability and leads to a shape-memory absorbent fiber.
Rapid prototyping (RP) technology has been used recently as a means for automated socket fabrication. Although the technology has proven to be promising and has truly automated the socket fabrication process, the structural integrity of RP sockets remains questionable. For the long term, unsupervised use of these 'unconventional' sockets, their material properties and structural integrity must be determined. This study investigated the structural integrity of polypropylene sockets manufactured using a polymer deposition technique, in which a socket is formed by a continuous strand of partially melted polypropylene that is spirally deposited according to the socket's cross-sectional contour. To investigate the problem of delamination of the socket, the tensile properties of the socket material were determined according to ASTM D638-99. The ultimate tensile strength was found to be approximately 13-23 per cent lower than that of polypropylene sheets that are at present normally used for socket fabrication. In order to improve the load-bearing capacity of the socket, it was reinforced using a double-wall arrangement at the distal region, where failure normally occurs. The structural integrity of the complete prosthesis was then investigated according to ISO 10328 (loading condition II). The prosthesis passed the static loading test registering only 12 mm permanent deformation, and it successfully completed a preliminary cyclic test of 250,000 cycles with no observable failure.
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