Karwinaphthol B is a compound of the naphthoquinone group. Karwinaphthol B is a chemical compound found in Bawang Dayak. Karwinaphthol B is one of the compounds considered to have antidiabetic effects. Diabetes Mellitus is a chronic disease that occurs when the body cannot produce enough insulin or cannot use insulin (insulin resistance) which causes blood glucose levels to rise (hyperglycaemia) under normal conditions. This study aims to see the potential of karwinaphthol B as a glucokinase inhibitor with parameters such as ∆G value and interaction of amino acid residues with molecular docking and pharmacophore studies using filter Lipinski, pkCSM, and SwissADME. The results of molecular docking showed that karwinaphthol B compound had potential as antidiabetic based on the ∆G value of -8.39 kcal/mole. Karwinaphthol B compound has an LD50 value of 2.168 mole/kg which is included in the non-toxic category; does not have hepatotoxicity, skin sensitization, and has a good bioavailability value. The interaction of Karwinaphthol B compounds with glucokinase enzymes at amino acid residues VAL62, ARG63, SER64,THR65, PRO66,  GLU67, GLY68, SER69, GLN98, MET210 , ILE211, TYR214, TYR215, CYS220, GLU221, MET235,  CYS252, LEU451, VAL452, and VAL455.

The reason for this study is to dissect Underlying Condition Displaying, in the desire for knowing the variables of human asset quality and administration quality that influence authoritative execution, public trust, and local area fulfillment, which can be distinguished as critical elements and unimportant variables. At the Division of Populace and Common Vault in Bogor Rule. Research strategy with quantitative methodology. Information assortment methods utilizing polls on respondents, concentrate on documentation, and perception. The exploration infers that the nature of HR decidedly affects administration quality, hierarchical execution, and public trust. Administration quality emphatically affects hierarchical execution and public trust. Hierarchical execution decidedly affects public trust and local area fulfillment, and public trust emphatically affects local area fulfillment. This study shows that the nature of HR is the primary consider further developing assistance quality, authoritative execution, public trust, and local area fulfillment.

Management of knowledge management to improve the performance of members of the Navy through talent management is very complex but can be applied in the organization of the Navy. This paper uses a qualitative method with a descriptive design; this descriptive research is used to find facts with interpretations that describe the nature of phenomena originating from groups or individuals originating from field findings. The results of this study include the lack of use of management knowledge to improve performance in talent management in the Navy, so the implementation of knowledge management needs to be done by taking into account aspects of the career path of members of the Indonesian Navy so that the implementation of talent management in the form of functional position analysis improves the careers and performance of members.

There is an encouraging hope that in 2020, there is a prediction that the Indonesian economy will increase further due to the APEC deadline, omnibus policy, and the demographic bonus is actually a mess due to the global catastrophe due to the COVID-19 pandemic. The sharp decline in the economic growth rate from 4.9% in the fourth quarter of 2019 to 2.07% in the first quarter of 2020 marked the beginning of the decline in Indonesia's economy class. Of course, this is not only experienced by Indonesia, but other countries, especially in the Southeast Asian region, have experienced this. However, there is only a promising opportunity at the end of 2021 when active cases of the Covid-19 pandemic can be suppressed and controlled after the success of vaccination in stages, so that Indonesia is considered a country that is able to control Covid-19 and managed to overcome it when countries in Europe is struggling to overcome the ferocity of covid-19 which has mutated to the delta variant.