Even after a year, the COVID-19 pandemic produced by the SARS-CoV-2 remains a major source of concerns for scientists. Surprisingly, the primary protease is a key target because of its role in viral propagation. As a result, no significant study in the field of adjuvant has been done too far. CAP stands for “Cellulose Acetate Phthalate”, an industrial polymer utilized in the enteric coating of tablets and capsules. CAP has been shown in certain trials to have anti-HIV properties by using the co-receptor location. Thus, CAP was tested against SAR-primary CoV-2's protease Mpro using in silico methods in the present study. Auto Dock was used to evaluate selected CAP molecules against SAR-CoV-2, and Discovery studio visualizer was used to create 3D and 2D interaction photos. CAP's binding energies were -3.05kcal/mol, -3.78kcal/mol, and -3.01kcal/mol during blind docking, site specific docking, and docking with a N3 inhibitor, respectively. Additionally, the discovery studio visualizer was utilized to look at interacting amino acids and 3D structures. Interestingly, the data from the discovery studio visualizer showed that it established H-bonds with Mpro residues, TYR37, TYR101, and LYS100 during blind docking and LYS88, TYR101, and LYS100 during site specific docking. The findings indicated that CAP binds non-competitively to co-receptor sites and that it may have synergistic effects with other medicines or medications. As a result, it's a good candidate for further testing in the lab and in the clinic.
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