Background: Early onset of stroke is a devastating illness and dyslipidaemia are widely accepted risk factors for coronary heart disease (CHD). High Apolipoprotein B (Apo B), low Apolipoprotein A 1 (Apo A 1 ) and the Apo B/Apo A 1 ratio are used as the predictors of stroke for CHD. Objective: To evaluate the association of Apo B, Apo A 1 and lipid profile with early onset stroke. Methods: This case-control study was conducted in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka from Jan'2008 to Dec'2008. Total 100 stroke patients of both sexes were included, diagnosed by CT scan and MRI. Fifty stroke patients of early onset (EOS-P; age d"45 yrs) were included as case and 50 stroke patients of late onset (LOS-P; age >50 yrs) were taken as control. Serum lipid profile (TAG, TC, LDL-C & HDL-C), lipid ratios (TC/HDL-C, LDL-C/HDL-C & TAG/ TC), Apo B, Apo A 1 , and Apo B/Apo A 1 ratio were measured in all patients. Mann Whitney U test, Odds Ratio, unpaired t-test were used for statistical analysis. Results: In this study, serum Apo A 1, and TAG were significantly higher in EOS-P than those of LOS-P. Again, with respect of cut off value, odds ratio of 2.29 indicates that high serum Apo B concentration is associated whereas odds ratio of 0.38 indicates that low serum Apo A 1 concentration is not associated with EOS Conclusion: From this study it can be concluded that, higher level of TAG is a risk factors for early onset stroke and high Apo B is associated with early onset stroke.