Soft computing is the fusion of different constituent elements. The main aim of this fusion to solve real-world problems, which are not solve by traditional approach that is hard computing. Actually, in our daily life maximum problem having uncertainty and vagueness information. So hard computing fail to solve this problems, because it give exact solution. To overcome this situation soft computing techniques plays a vital role, because it has capability to deal with uncertainty and vagueness and produce approximate result. This paper focuses on application of soft computing techniques over hard computing techniques.

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Synopsis N-phenyl-p-phenylenediamine (N-PPDA), an industrial intermediate and hair dye ingredient, has been implicated in a variety of toxic symptoms including cutaneous manifestations. However, the role of physiological factors that may determine and modify its absorption and transport within and through the skin is not fully understood. The present study reveals that N-PPDA binds readily to skin showing saturation kinetics with Km and V(max) of 2.54 x 10(-4) M and 4.76 mumol g(-1) skin, respectively. The uptake was dependent upon the area of skin, concentration of the amine, exposure time, temperature and pH of the vehicle. Heat treatment facilitated the binding but temperatures abouv 50 degrees caused significant lowering of the uptake, indicating the possible involvement of collagen matrix. Skin lipids also contributed in the binding of N-PPDA. Bioinhibitors such as KCN, sodium arsenate, NaF, N-ethylmaleimide, cycloheximide, iodoacetic acid and 2,4-dinitrophenol had no effect on the uptake potential, suggesting it to be a non-energy dependent process. Most of the skin-bound N-PPDA was effluxed through serum proteins reaching the target organs via systemic circulation.

A simple, quick and sensitive procedure is described to monitor urinary clearance of aromatic amines in industrial workers. Estimation is based on the measurement of coloured Schiff's bases developed with 4-dimethylaminocinnamaldehyde-organic acid reagent. Extraction of amines in water saturated butanol ensured 89-97% recovery from biological samples with a coefficient of variation of less than 8%. Regression analyses of the absorbance-concentration curves with different aromatic amines showed excellent correlation coefficient and a high molar absorptivity with the lowest detection limits ranging between 0.05-0.12 microgram ml-1. The proposed reagent has additional use as a spray reagent to detect amine spots on chromatograms. Low final acidity ensures estimates of free amines without causing hydrolysis of conjugated amines.