This study aimed to investigate the impact of VCO and castor oil compositions on the physicochemical properties of liquid soap from patikan kebo (Euphorbia hirta) extract and compare it with the marketed liquid hand-soap. The liquid hand-soap was manufactured by adding patikan kebo extract with VCO and castor oil as fatty acid sources. The concentration of VCO and castor oil were varied in 5 formula with ratio 1 : 0, 3 : 1, 1 : 1, 1 : 3, and 0 : 1 of 200 mL of soap perspectively. Several tests such as organoleptic inspection, homogeneity, density, viscosity, foam volume and stability, pH, insoluble materials, free fatty acids, total active ingredients, and total plate number, were performed to determine the physicochemical properties of prepared handsoap. The results of the five formulas were known to the greater VCO the higher the viscosity and percent height of foam, the greater the castor oil the higher the value of specific gravity The five liquid soap formulas produced meet the requirements of SNI 2588-2017. The second liquid soap formula with a ratio of VCO and castor oil 3: 1 was declared to be the best product with free fatty acid 0.78%, pH 8.31, total active ingredient 24.3%, ethanol insoluble material 0.29%, specific gravity 1.09 g/mL, foam high stability 82.85%, and no colonies in testing the Total Plate Figures. It can be concluded that variations in the concentration of VCO and castor oil may affect the physicochemical properties of liquid soap for hand washing extracted from Patikan kebo.