Antibiotics U 1200 Synthesis, DNA Binding and Cytotoxicity of New Pyrazole Emodin Derivatives. -A series of new anthrapyrazoles (XI) (8 examples) derived from emodin (I) with cationic amino side chains is synthesized. Compared with emodin, all derivatives show significantly higher DNA binding affinity and much more potent cytotoxity against different tumor cell lines. Derivatives having a monocationic alkyl side chain [cf. (XIa), (XIb)] exhibit the highest effects. -(TAN, J.-H.; ZHANG, Q.-X.; HUANG, Z.-S.; CHEN, Y.; WANG, X.-D.; GU, L.-Q.; WU*, J. Y.; Eur.