OBJECTIVETo quantitatively explore the expression of Syndecan-1 and heparanase-1 in esophageal cancer tissue as well as their relationship with the clinicopathological factors, in order to evaluate their roles in tumor invasion and metastasis. METHODS Real-time fluorescence quantitative PCR (Q-PCR) was used to analyze the expression levels of Syndecan-1 and heparanase-1 genes，participants included 67 cases with esophageal cancers and 32 healthy volunteers. RESULTS The expression of Heparanase-1 gene in esophageal cancers was higher than that in normal esophageal tissue (P < 0.001), and the expression of Syndecan-1 gene in the normal esophageal tissue was higher compared with esophageal cancers (P < 0.001). The positive rates of Syndecan-1 and Heparanase-1 gene in esophageal cancer were 13.4% (9/67) and 85.1% (57/67). The expression of Syndecan-1 and Heparanase-1 genes was signifi cantly related to diff erentiation, depth of infi ltration, lymph node metastasis, vessel metastasis, and TNM stages of disease (P < 0.05). In an attempt to measure the association between the 2 agents, this study found that the expression of Syndecan-1 mRNA had a significantly negative correlation with the expression of Heparanase-1 mRNA by using Spearman rank correlation test (OR = -0.572, P < 0.001). CONCLUSION Syndecan-1 and Heparanase-1 play important roles in the invasion and metastasis of esophageal cancer. The reduction of Syndecan-1 and/or the increase of Heparanase-1 may influence the invasion and metastasis of malignant tumors. Thus the combination assay of Syndecan-1 and Heparanase-1 may contribute to the diagnosis and treatment of malignant tumors.KEY WORDS: Syndecan-1, esophageal neoplasms, neoplasm invasiveness, neoplasm metastasis, PCR.

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With the continuous development of social science and internet technology, media convergence has become an inevitable trend in the development of the media industry, and the current society has entered the era of media convergence. In this environment, media convergence has emerged at a pivotal period. Traditional media and emerging media are integrating with one another, putting forward not only new but also higher requirements for the traditional publishing industry in China. Under the development trend of this kind of media, the digital publishing industry chain is undergoing profound changes, and the publishing industry must actively upgrade its thought ideas, operation mechanism, information dissemination, and many other optimization transformations to ensure that under media convergence, there is stability of the traditional publishing industry, sustainable innovation, as well as development. This paper will make a detailed analysis of the characteristics of media convergence and explore the difficulties and development strategies of media industry upgrading in the era of media convergence.